Here, we reported 16 altered TF proteins NP1L4, BBOX1, CYTC, RNAS4, PCD, RNT2, AL1A3, SYSC, TPIS, CLH1, PGAM1, EIF3L, 5NTC, HNRNPA2B1, PYGL, and ERO1α that were significantly upregulated in AD group. Here, PYGL is linked to Alzheimer disease.