In a murine model of AD, reduced cholinergic signaling negatively affects the transcriptional process mediated by HNRNPA2B1.30,31 In our present study, HNRNPA2B1 was upregulated in the AD group, which seems to be in contrast to the observations in AD model mice.30,31 This difference may be explained by the fact that the participants in our study had mild AD dementia, and thus may have had less robust cholinergic deficiency compared to AD mice. Here, HNRNPA2B1 is linked to Alzheimer disease.