Here, we reported 16 altered TF proteins NP1L4, BBOX1, CYTC, RNAS4, PCD, RNT2, AL1A3, SYSC, TPIS, CLH1, PGAM1, EIF3L, 5NTC, HNRNPA2B1, PYGL, and ERO1α that were significantly upregulated in AD group. This evidence concerns the gene BBOX1 and Alzheimer disease.