Furthermore, VEGF-A reportedly binds Aβ peptide and co-localizes with amyloid plaques in the AD brain, and VEGF-A expression is thought to positively correlates with AD severity.39 Additionally, VEGF-A has been shown to be protective against AD-related neurotoxicity.40 Our present results may indicate that vascular deficits and AD-related protein already present in the brain during mild AD dementia. This evidence concerns the gene VEGFA and Alzheimer disease.