Here, we reported 16 altered TF proteins NP1L4, BBOX1, CYTC, RNAS4, PCD, RNT2, AL1A3, SYSC, TPIS, CLH1, PGAM1, EIF3L, 5NTC, HNRNPA2B1, PYGL, and ERO1α that were significantly upregulated in AD group. The gene discussed is SPAG1; the disease is Alzheimer disease.