PPARA and neoplasm: Moreover, targets such as mTOR, COX-2, peroxisome proliferator-activated receptor alpha/gamma (PPARα/γ), and the glucocorticoid receptor have attracted attention as promising avenue to target the inflammatory framework of the HL-related tumor microenvironment (Konopleva et al., 2004; Solimini et al., 2007; Luo et al., 2009; Harrer et al., 2023a; Cuéllar Mendoza et al., 2024).