In HL tissues, few malignant CD30-positive Hodgkin–Reed–Sternberg (H-RS) cells are surrounded by an extended inflammatory stromal reaction comprising heterogeneous, non-neoplastic cell populations, consisting of a broad variety of not only hematologic cells but also mesenchymal cells and a variable degree of fibrosis in the tumor microenvironment (Dürkop et al., 1992; Steidl et al., 2011; Cader et al., 2018; Connors et al., 2020; Ribatti et al., 2022). This evidence concerns the gene TNFRSF8 and Hodgkins lymphoma.