MTOR and Hodgkins lymphoma: Elevated levels of reactive oxygen species, as well as spontaneous/therapy-induced DNA damage, ER stress response, and aneuploidy, which are frequently found in HL, cause mTOR adaption to stress responses(Figure 2) (Sen et al., 1990; Bur et al., 2014; Cuceu et al., 2018; Daniel et al., 2019; Alao et al., 2021; Mafi et al., 2023; Marini et al., 2023).