For Instance, the E2 enzyme UBE2T inhibited CD8+ T-cell infiltration and expression of immune-promoting factors (IFN-γ, TNF-α and IL-2) in lung adenocarcinoma by activating the glycolytic pathway upon binding to FOXA1 (Pu et al., 2024). The gene discussed is CD8A; the disease is lung adenocarcinoma.