AKT1 and hepatocellular carcinoma: Specifically, exogenous interleukin-8 has been shown to promote cellular invasion and elevate the levels of integrin β3, phosphorylated phosphoinositide 3-kinase (p-PI3K), and phosphorylated protein kinase B (p-Akt), thereby influencing the invasion and metastasis of hepatocellular carcinoma (Sun F. et al., 2019).