KDR and acute kidney injury: Our findings that the pooled incidence of proteinuria was higher than that of renal function impairment reflected by the diagnosis of AKI or increased serum creatinine and also higher in VEGFR inhibitors containing therapies compared to chemotherapy alone are consistent with literature on glomerular injury caused by targeted agents, particularly VEGFR inhibitors (den Deurwaarder et al., 2012; Estrada et al., 2019; Izzedine et al., 2010).