Papers with the keyword “Risk factor” investigate the role of high-density lipoprotein, oxidized phospholipids, and Lp(a) in elucidating the deposition of lipogenic substances as one of the key risk factors contributing to CAVS (Myasoedova et al., 2018; Graham et al., 2016), it also clarified that oxidative stress, inflammation, and coronary artery disease are all risk factors for aortic valve calcification (Cho et al., 2018). The gene discussed is LPA; the disease is aortic valve calcification.