Patients with psoriasis have hypomethylated human leukocyte antigen (HLA)-DMA and G protein-coupled receptor 128 (GPR128) genes, but they have hypermethylated tenascin-XB (TNXB) and macrophage stimulating 1 receptor (MST1R) genes [32]. The gene discussed is ADGRG7; the disease is psoriasis.