ACTN2 and heart failure: Hi-C was used to scrutinize the 5-kilobase segment surrounding the cardiomyocyte target gene and its neighboring gene-promoter interactions, and the findings revealed that the ATAC-seq peak corresponded to the promoter region of the ACTN2 gene, a gene now recognized as being implicated in heart failure (Sabino et al., 2022; Arvanitis et al., 2020).