The association between the IL-1α +4845G/T, IL-1β +3953C/T, IL-1RA +2018T/C, and IL-1β -511C/T gene polymorphisms and pneumoconiosis was examined in 3 studies involving 645 patients and 581 controls, 4 studies involving 800 patients and 676 controls, 6 studies involving 609 patients and 704 controls, and 7 studies involving 905 patients and 1,006 controls, respectively. Here, IL1A is linked to pneumoconiosis.