The results of overall analyses disclosed that IL-6 -174 was not related to the pneumoconiosis susceptibility (C vs. G: OR = 0.95, 95%CI = 0.79-1.13, p = 0.538; CC vs. GG: OR = 1.00, 95%CI = 0.70-1.44, p = 0.983; CG vs. GG: OR = 0.75, 95%CI = 0.37-1.50, p = 0.413; CC+CG vs. GG: OR = 0.82, 95%CI = 0.47-1.42, p = 0.477; CC vs. CG+GG: OR = 1.05, 95%CI = 0.76-1.45, p = 0.768). The gene discussed is IL6; the disease is pneumoconiosis.