The IL-1RA +2018 polymorphism was evidently related to the pneumoconiosis risk (C vs. T: OR = 1.60, 95%CI = 1.20–2.13, p = 0.001; CC vs. TT: OR = 2.01, 95%CI = 1.35–2.99, p = 0.001; CC + CT vs. TT: OR = 1.65, 95%CI = 1.11–2.46, p = 0.013; CC vs. CT + TT: OR = 1.87, 95%CI = 1.28–2.74, p = 0.001, Figure 4). This evidence concerns the gene IL1RN and pneumoconiosis.