Another study assessed the association between IL-1β +3953, IL-6 -634, IL-12β +1188 and vascular endothelial growth factor A (VEGFA) rs2010963 and the risk of silicosis and reported that the IL-1β +3953T-allele was significantly related to silicosis susceptibility, which was a hazard factor in coal miners (47). This evidence concerns the gene IL12B and silicosis.