Compared with the sham acup group, patients treated with acupuncture showed lower levels of TNF-α (Figure 4A), IL-6 (Figure 4B), and IL-1β (Figure 4C), suggesting that acupuncture inhibited the inflammatory response during the perioperative period, which might help reduce the neuroinflammation and thus to alleviate cognitive impairment. This evidence concerns the gene IL6 and Cognitive impairment.