TNF-α, as a key proinflammatory factor, activates NF-κB and MAPK signaling pathways by binding to its receptors TNFR-1 and TNFR-2 (Liu et al., 1996; Bradley, 2008), aggravating cardiac inflammatory damage and promoting myocardial fibrosis and heart failure (Franssen et al., 2016). This evidence concerns the gene NFKB1 and Myocardial fibrosis.