It is worth noting that vIRF1 can interact with lymphoid enhancer binding factor 1 (Lef1), activate circARFGEF1 transcription and regulate cell migration through the circARFGEF1/miR-125a-3p/glutaredoxin 3 (GLRX3) axis, contributing to tumor development (Yao et al., 2021). Here, LEF1 is linked to neoplasm.