Previous experiments have demonstrated that circBACH1 promotes HBV replication and liver cancer development by regulating the miR-200a-3p/mitogen-activated protein kinase kinase kinase 2 (MAP3K2) axis, while circ-ARL3 enhances HBV replication by sponging miR-1305 (Rao et al., 2021; Du et al., 2022a). The gene discussed is MAP3K2; the disease is liver cancer.