It was found that an increase in autophagic markers, such as P62 (n = 4, 221.10% ± 25.90%, p = 0.005 vs. N2A; Figures 3A,B) and LC3 II/I (n = 4, 173.20 ± 25.21%, p = 0.027 vs. N2A; Figures 3A,C) in N2AAPP cells, indicating enhanced autophagy accumulation in Alzheimer’s disease. Here, MAP1LC3A is linked to early-onset autosomal dominant Alzheimer disease.