Supportive of this hypothesis are several studies, which found that exergaming increased BDNF levels in chronic stroke, older adults and Parkinson’s disease patients (Monteblanco Cavalcante et al., 2021; Huang et al., 2022; Schaeffer et al., 2022), as well as IGF-1 and other neuroplasticity-indicative biomarkers in people with mild cognitive impairment (Nath et al., 2023). The gene discussed is BDNF; the disease is Cognitive impairment.