Similarly, histological aspects such as tumour budding, perineural invasion and lymph node involvement, along with molecular markers such as Kirsten rat sarcoma virus (KRAS), B-Raf proto-oncogene (BRAF), microsatellite instability (MSI) and CDX2 can help to establish a prognosis and optimise treatment.9 This evidence concerns the gene BRAF and neoplasm.