Another study on chronic benzene poisoning (CBP) patients found 13 significantly deregulated miRNAs, primarily associated with cancer pathways, targeting genes such as VEGFA (Vascular Endothelial Growth Factor A) and PTEN (Phosphatase and Tensin Homolog) (Bai et al., 2014; Mozzoni et al., 2023).Genetic susceptibility and polymorphisms in enzymes involved in PAH metabolism, such as CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) and GSTP1 (Glutathione S-Transferase Pi 1), may contribute to PAH-related toxicity. This evidence concerns the gene PTEN and pulmonary arterial hypertension.