In addition, FOXO1 is an important factor in proteolysis, and increased FOXO1 expression during sepsis is a key factor that causes SAW (Smith et al., 2010; Castillero et al., 2013).This suggests that copper-induced cell death may be involved in the pathomechanism of SAW through the FOXO-related signaling pathway. This evidence concerns the gene FOXO1 and Sepsis.