One view is that copper levels are elevated in patients with sepsis (Zhang et al., 2023; Akkaş et al., 2020), and animal studies have shown that inhibition of copper levels attenuates caspase-1 activation and reduces lymphocyte death, which in turn increases survival in models of sepsis (Deigendesch et al., 2018). The gene discussed is CASP1; the disease is Sepsis.