ACTA2 and Hepatic fibrosis: One study reported that 14 weeks of both HIIT and moderate-intensity continuous training (MIT) suppressed the expression of liver fibrosis markers COL1A1 and actin alpha 2, smooth muscle (Acta2) in NASH mice induced by a high-fat, high-carbohydrate diet, while also downregulating the expression of isopentenyl-diphosphate delta isomerase 1 (Idi1) mRNA.