PRKN and Myocardial fibrosis: (19) demonstrated that resistance exercise at 65%-70% of peak oxygen uptake for 60 minutes per day A regimen of five days per week, for eight weeks, inhibited myocardial fibrosis and promoted light chain 3-I (LC3I), LC3II and mitochondrial autophagy PTEN-induced putative kinase1 (PINK1) in HF mice, as well as Parkin protein expression and downregulating P62 protein expression (19).