TP53 and renal fibrosis: A recent study demonstrated that 12 weeks of aerobic exercise was able to ameliorate renal fibrosis associated with aging by inhibiting the TGF-β1/p53/miR-34a signaling pathway, upregulating the expression of the anti-aging protein Klotho, and further inhibiting its downstream TGF-β1/Smad3 and β-linker signaling pathways (141).