Specifically, in mice and rats with high-fat diets and T2DM, running training activated AMPK in the kidneys, increased the phosphorylation level of UNC-51-like kinase 1 (ULK-1) and inhibited the activity of mammalian target of rapamycin complex 1(mTORC1), respectively. The gene discussed is ULK1; the disease is type 2 diabetes mellitus.