It was demonstrated that Doxorubicin (DOX) induced cardiotoxicity in mice exhibited a reduction in myocardial fibrosis, Uncoupling Protein 2 (UCP2), endothelial markers (CD31 and E-cadherin), and autophagy proteins (Beclin-1 and LC3II/LC3I) expression, while mesenchymal markers (α-SMA and Vimentin) and p62 expression were increased (74). This evidence concerns the gene UCP2 and Myocardial fibrosis.