It was demonstrated that eight weeks of platform running exercise promoted irisin expression, inhibited myeloid differentiation factor 2 (MD2)-TLR4 binding and suppressed the expression of downstream inflammatory factors IL-6, IL-1β, TNF, chemokine (C-C motif) ligand 2 (CCL2), intercellular adhesion molecule-1 (ICAM1), and vascular cell adhesion molecule-1 (VCAM1) in the livers of NAFLD mice, as well as COL1A1 and TGF-β (156). This evidence concerns the gene ICAM1 and metabolic dysfunction-associated steatotic liver disease.