Another study demonstrated that swimming exercise for 15 minutes per day, 5 days per week for 8 weeks inhibited myocardial fibrosis, apoptosis, and ROS production, and upregulated Sirtuins3 (SIRT3) expression and antioxidant enzyme SOD2 activity in aged MI mice (70). The gene discussed is SOD2; the disease is Myocardial fibrosis.