The well-designed OPTIMIST trial did include a group of patients predicted to be hyper-responders (AFC > 15) and found that, compared to a “standard” starting dose of 150IU of FSH per day, 100IU of FSH per day was associated with similar cumulative live birth rate (CLBR) and a lower rate of any grade of OHSS, though no difference in the rate of severe OHSS (61). Here, BRD2 is linked to ovarian hyperstimulation syndrome.