In addition, some studies66,67 have shown that chemokine CXCL10 and CXCL3 play a role in the progression of atherosclerosis, but our study found that CXCL10 and CXCL3 play a role in alleviating AS only by promoting M0 to M2b macrophages and suggest that CXCL3 and CXCL10 may be important chemokines in promoting the polarization of M2B macrophages. This evidence concerns the gene CXCL3 and atherosclerosis.