The urinary sACR is very effective in predicting AKI, even having a better predictive value (area under the curve 0.725; 95% confidence interval 0.676-0.774) than NGAL and plasma cystatin-C with a cut-off value of ≥ 66.7 μg/mg as having the best diagnostic accuracy [17]. The gene discussed is CST3; the disease is acute kidney injury.