According to Atilla et al. (42), there was a reduction in IL-6 levels in the gingival crevicular fluid of kidney transplant patients with cyclosporin induced gingival enlargement compared to sites with gingivitis, although these patients exhibited significantly higher IL-1β levels at sites with gingival enlargement compared to both sites without enlargement and healthy sites in healthy subjects. Here, IL1B is linked to gingival overgrowth.