In a multivariable model (Table 2), adding LEF1-AS1 along with pre-existing comorbidities and moderate acute COVID-19 significantly enhanced its association with the risk of cardiovascular and neurological complications (Akaike Information Criterion (AIC) of 110.428 for the model with LEF1-AS1 vs 114.354 without LEF1-AS1, p = 0.015). The gene discussed is LEF1; the disease is COVID-19.