Core clock genes such as CLOCK, Bmal1, PER, and CRY regulate circadian rhythms, which influence the timing and occurrence of seizures in many types of epilepsy (Li et al., 2017; Castro et al., 2018; Jin et al., 2020; Kreitlow et al., 2022; Niu et al., 2025). Here, CLOCK is linked to epilepsy.