It has been shown that iNOS expression is significantly impaired in astrocytes knocked down for LCN2, which highlights the critical role of LCN2 in promoting the classical activation of the astrocyte pathway, suggesting that it may be one of the key factors exacerbating cerebral ischemia/reperfusion injury under certain conditions (Zhao et al., 2019). The gene discussed is LCN2; the disease is brain ischemia.