This article comprehensively reviews the mechanism of LCN2 in cerebral ischemia/reperfusion injury, not only aims to provide new ideas and methods for the treatment of ischemic stroke, but also hopes to explore the possibilities of LCN2 as a potential therapeutic target by systematically sorting out the results of the existing research, so as to lay a solid theoretical foundation for the subsequent preclinical studies and clinical trials. The gene discussed is LCN2; the disease is brain ischemia.