YEATS4 and central nervous system cancer: Furthermore, as glioma amplified sequence 41 (GAS41) is a new regulator of NOTCH signaling via modulating H2A.Z deposition, evidence indicated that GAS41 interacts with H2A.Z.2 to activate NOTCH‐1 signaling and its downstream, which promote PC stemness and resistance to GEM [56, 57].