According to the division of AIDS (DAIDS) table for grading the severity of adult adverse events: 69 events were of grade 1 severity, 24 events of grade 2 severity, 9 events of grade 3 severity, and 1 event was of grade 4 severity.24 Significantly more elevated ALT adverse events occurred in CYP2B6 intermediate (38.8%) and slow metabolisers (38.8%), than in extensive metabolisers (22.3%, P = 0.02). The gene discussed is CYP2B6; the disease is AIDS.