ROCK1 and Alzheimer disease: Considering that ROCK1 and ROCK2 knockdown had opposite effects on endogenous human Aβ levels in SH-SY5Y cells, and that inhibition by SR3677 decreases both endogenous Aβ in SH-SY5Y cells, and Aβ in 5XFAD mouse brains, ROCK2 specific inhibitors such as SR3677 may be of importance in AD treatment.