SR3677 [IC50 of 3 nM for ROCK2 and 56 nM for ROCK1 (Feng et al., 2008)] also suppresses β-site APP cleaving enzyme 1 (BACE1) activity, and attenuates Aβ production in an AD mouse brain (Herskowitz et al., 2013). The gene discussed is ROCK2; the disease is Alzheimer disease.