GLP1R and cardiac hypertrophy: Furthermore, GLP-1 agonist liraglutide has been shown to ameliorate myocardial hypertrophy in hypertensive rats, potentially through ROCK2 decrease (Fan et al., 2020), as in H9C2 cells, GLP-1 decreased ROCK2, and Y27632 further decreased AngII effects on hypertrophic gene ANP expression when combined with GLP-1 (Fan et al., 2020).