In addition, this study utilized the PSMD11- and PSMD14-knockdown pancreatic cancer cell lines PANC-1, MIA PaCa-2 and BxPC-3 for functional phenotyping and verified the cancer-promoting functions of PSMD11 and PSMD14 at the in vitro level, which may play key roles in pancreatic carcinogenesis and may be potential targets for pancreatic cancer treatment. This evidence concerns the gene PSMD11 and cancer.