TAF15 functions primarily as a transcriptional co-activator by interacting with components of the transcription machinery, including RNA polymerase II and other transcription factors, to regulate gene expression.2 TAF15 contains RNA-binding motifs, enabling it to influence RNA splicing, transport, and stability.3 Dysregulation or mutations in TAF15 have been implicated in certain cancers and neurodegenerative diseases, highlighting its critical role in cellular homeostasis.4 The gene discussed is TAF15; the disease is cancer.