Neutralizing ACA against Type I IFNs such as IFNα, IFNβ, and IFNω are found in various autoimmune diseases such as SLE, SS, myasthenia gravis, autoimmune polyglandular syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX) (31). This evidence concerns the gene IFNA2 and Autoimmune polyendocrinopathy type 1.