Interestingly, a positive correlation was observed between galectin-9 and type I IFN-inducible genes, such as MX1 and IFIH1, at the mRNA level in PBMCs, suggesting a potential synergistic or interconnected role of galectin-9 and type I IFN signaling in fibrosis associated with anti-MDA5 antibody-positive DM (75). This evidence concerns the gene IFIH1 and dermatomyositis.