ITK and asthma: Furthermore, our single-nucleus sequencing of vagal ganglia in response to A. alternata induction of asthma showed an upregulation of immune response genes such as Bcl6 (B-cell lymphoma 6), Il6 (interleukin-6), Itk (IL2-inducible T-cell kinase), and Cyp26a1 (cytochrome P450 26 subfamily A), which was similar to a recent single-cell RNA sequencing analysis of lung-innervating vagal neurons in response to ovalbumin induction of asthma (56).