Therefore, reactivity and frequency of IgE type antibodies against dsDNA, SSA/Ro52, SSA/Ro60, and SSB/La were analysed concerning clinical manifestations including SLEDAI, number of organ manifestations, cutaneous, renal, pulmonary, cardiac, musculoskeletal, gastrointestinal, and haematological manifestation in 90 patients with SLE (Figure 4, Supplementary Table S3). The gene discussed is TRIM21; the disease is systemic lupus erythematosus.