FTO and breast carcinoma: Moreover, FTO also mediates the m6A modification of the pro-apoptotic gene Bcl-2/adenovirus E1B 19kDa-interacting protein 3 (BNIP3), reduces BNIP3 stability, and induces its degradation, thereby inhibiting breast cancer cell apoptosis, suggesting that regulating the level of cell apoptosis may be a potential target for FTO to exert its biological functions (15).