CD8A and neoplasm: There was a dominant population of GZMB+ cytotoxic CD8 T cells, carrying TCRs that were also detected at the site of EN-like irAE (Figure 5B), alongside a smaller subset that shared nearly identical functional markers but was uniquely enriched for specific TRBV and TRAV sequences; these T cells had TCRs that were detected in both the tumor and EN-like irAE biopsy (Figure 5B).