Although sparse HLA typing data were available for prior reported cases, upon comparing the patients’ HLA typing, our case shared HLA-B*35 and HLA-DPB1*04, two frequently carried alleles, with a previously reported EN-like irAE patient who had a prior medical history of hypothyroidism (10), suggesting the association between HLA genotype and the toxicity pathogenesis. Here, HLA-DPB1 is linked to hypothyroidism.