Some studies even suggest that the immunosuppressive effect mediated by EGFR mutations may be an important reason for limiting the efficacy of ICIs, i.e., EGFR mutant NSCLC recruits immunosuppressive cells by secreting cytokines to repel anti-tumor immune cells, thus creating an immune-silencing microenvironment (11, 29, 30). Here, EGFR is linked to non-small cell lung carcinoma.