TTN and myositis disease: From a broader perspective, it has been proposed that neuromuscular auto-Abs, including anti-titin, anti-skeletal muscle, anti-cardiac muscle, anti-Lipoprotein Receptor-Related Protein 4 (LRP4), anti-Ryanodine Receptor (anti-RyR), and anti-AChR, could be used as biomarkers for the diagnosis and potential prediction of ICI-induced neuromuscular diseases, such as myositis and severe MG (35).