During the early phases of helminth infection, alarmin signals such as interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) are released by non-hematopoietic cells in response to tissue damage and act to induce rapid proliferation and expansion of group 2 innate lymphoid cells (ILC2). Here, TSLP is linked to helminthiasis.