Using the threshold P< 0.05 plus log2 FC> 1.0 as the selection criteria, seven candidate lncRNAs (LINC00494, TSP0AP1-AS1, MCM3AP-AS1, LINC01588, OIP5-AS1 and THUMPD3-AS1, LINC01094) were selected for further verification by RT-qPCR in the PBMC of 38 cases with RA and 36 HCs (Table 2). The gene discussed is OIP5; the disease is rheumatoid arthritis.