In conclusion, the outcomes of our study implied that the expression of lncRNAs (LINC00494, TSP0AP1-AS1, MCM3AP-AS1, LINC01588, and OIP5-AS1) may be changed in the PBMC of RA patients, underscoring their potential utility to serve as biomarkers for RA. This evidence concerns the gene OIP5 and rheumatoid arthritis.