We have extensively characterized the role of VMH GI neurons in the sympathoadrenal counterregulatory response to insulin-induced hypoglycemia (Fioramonti et al., 2013; Fioramonti et al., 2010; Santiago et al., 2016; Song and Routh, 2006; Zhou and Routh, 2018). This evidence concerns the gene INS and Hypoglycemia.