ADORA3 and neoplasm: Given that derivatives bearing a 2‐phenethylamino group at the N6‐position of Ado, such as AR 292, were found to exert higher A3AR affinity and selectivity than the corresponding N6‐(2,2‐diphenylethyl) analogs, such as AR 357 [17], and the latter showed the highest anti‐tumor activity, the A3AR antagonist‐induced anticancer effects seem to be mediated by both A3AR‐dependent and ‐independent mechanisms.