As shown in Fig. 1A, A3AR ligands were able to decrease PCa cell growth, reaching Growth Inhibition 50 (GI50) values of 3.5 μm in LNCaP, 7 μm in DU‐145, and 7 μm in PC3 for AR 292, while for AR 357, LNCaP had a GI50 of 15 μm, DU‐145 18 μm and PC3 12 μm. Here, ADORA3 is linked to posterior cortical atrophy.