TARDBP and amyotrophic lateral sclerosis: The study of the post-mortem distribution patterns of TDP-43 inclusions across 76 ALS brains parcellated these into four so-called ‘stages’.103 In those cases presenting with minimal TDP-43 pathology (Stage 1), the lesions were identified within the agranular motor cortex, brainstem motor nuclei of cranial nerves V, VII and X–XII, and spinal cord α-motor neurons.