This stands in contrast to FTD-predominant syndromes, where post-mortem evaluations have consistently revealed characteristically asymmetric TDP-43 distribution, with a pronounced presence in the language-dominant hemisphere.104-106 While TDP-43 subtypes, such as type C, are frequently associated with semantic variant primary progressive aphasia (svPPA)—a subtype of FTD characterized by asymmetric temporal lobe degeneration—there is currently no specific information on TDP-43 subtypes in ALS studies, which limits our understanding of their potential contribution to asymmetry in ALS. Here, TARDBP is linked to amyotrophic lateral sclerosis.