Initially identified in the rare neurological disorder 2‐hydroxyglutaric aciduria, D‐2‐Hydroxyglutarate (2‐HG) gained significant attention in 2009, when genome‐wide sequencing of gliomas and acute myeloid leukemia (AML), coupled with groundbreaking research on isocitrate dehydrogenases (IDH), uncovered its synthesis by mutated IDH1 (mIDH1) or IDH2 (mIDH2) enzymes.159, 160, 161, 162, 163, 164. The gene discussed is IDH2; the disease is glioma.