Besides, the levels of p-tau217 (FC = 1.2–1.3, β = 0.5–1.1, p < 0.002), p-tau231 (FC = 1.4–1.5, β = 2.7–4.3, p < 0.001), and NfL (FC = 1.6–2.1, β = 41.7–65.9, p < 0.003) were increased in other dementias compared to those in the HC group (Fig. 1). The gene discussed is NEFL; the disease is dementia.