As a result, we found that the α-synuclein level was the best for detecting PSP-v and bvFTD subtypes at cut-off values of 3957.3 pg/mL and 6705.0 pg/mL, achieving an AUC of 0.81 and 0.74, respectively, while the levels of GFAP and NFL presented good diagnostic performance in svFTD and nfvFTD at cut-off values of 22.32 pg/mL and 85.7 pg/mL, with an AUC of 0.74 and 0.69, respectively (Fig. 5). This evidence concerns the gene SNCA and supranuclear palsy, progressive, 1.