The p-value for the product term of PM2.5-CP PRS (Fig. 1A), PM2.5-SCZ PRS (Fig. 1B), PM2.5-MDD PRS (Fig. 1C), PM2.5-AD PRS (Fig. 1D), and PM2.5-APOE genotype (Fig. 1E) was 0.7760, 0.3527, 0.7836, 0.3413, and 0.8452, respectively. This evidence concerns the gene APOE and major depressive disorder.