The results revealed that the plasma levels of T, LH, and the LH/FSH ratio were significantly increased (P < 0.01), whereas the levels of E2, FSH, and P4 were significantly decreased (P < 0.01) in group 2 compared with group 1 (Fig. 6, Supplementary Table 3), demonstrating the characteristic hormone imbalance commonly observed in PCOS individuals. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.