IL6 and polycystic ovary syndrome: When utilizing deCODE as the exposure, the results demonstrated that IL6 still exhibited a significant negative causal relationship with PCOS, with a substantial effect size (IVW: OR = 0.35, 95% CI: 0.13–0.98, P = 4.62e − 2) (Fig. 3 and Additional file 1: Table S6).