IL6R and polycystic ovary syndrome: Employing two-sample MR analysis, we juxtaposed cytokine pQTLs from the Fenland with PCOS GWAS summary statistics from Tyrmi JS et al. Regrettably, in this analysis, plasma IL6R levels remained a protective factor for PCOS but did not achieve statistical significance (WR: OR = 0.73, 95% CI: 0.30–1.78, P = 4.86e − 01) (Fig. 2 and Additional file 1: Table S5).