In the subgroups of high Gleason score, 7 SNPs in 3 genes (MTR, GAS5, mTOR) were associated with an increased risk of PCa (OR = 1.3–4.54, highest: GAS5 rs1951625 G > A) [16, 32, 50],while mTOR rs2295080 T > G, Vavs rs12410676 G > A and CYR61 rs1801133T > C had an opposite effect (OR = 0.53–0.79) [29, 35, 40, 50]. Here, MTR is linked to posterior cortical atrophy.