Among smokers, 13 polymorphisms in 13 gene (COX-2, NFKBIA, miR-143/miR-145, Raptor, Vavs, GAS5, mTOR, Hsa-miR-23a, NFKB1) were associated with increased PCa risk. The gene discussed is NFKB1; the disease is posterior cortical atrophy.