Regarding the reduced risks of PCa, 8 of 11 polymorphisms in the 8 genes (XPC, Vavs, NFKB1, MTHFR, interleukin-1A (ILIA), DNMT3B, DNMT1, CYR61 (IGFBP10)) 2 unmapped SNPs (rs16901966 A > G, rs10090154 C > T) were shown to be associated with reduced risk in men with PCa, conferring odds ratio (OR) ranged from 0.41–0.88. This evidence concerns the gene DNMT3B and posterior cortical atrophy.