In subgroups of low Gleason score, 4 SNPs in 4 genes (PRKCI, DNMT1, DNMT3B, XPC) were associated with a decreased risk of PCa (OR = 0.38–0.72, lowest: PRKCI rs4955720 C > A) [25, 26, 37], while the other 4 SNPs in PC3 and mTOR had a positive association (OR = 1.25–1.58) [17, 50]. Here, DNMT3B is linked to posterior cortical atrophy.