In non-smokers, 5 variants in 4 genes (NFKBIA, IL6, Raptor, GAS5) were considered to increase the risk of PCa (OR = 1.38–4.78, highest: GAS5 rs17359906G > A) [22], while PRKCI rs4955720 C > A (OR = 0.43 and XPCA rs1870134 G > C (OR = 0.75) were considered to reduce the risk [25, 31, 37]. This evidence concerns the gene IL6 and posterior cortical atrophy.