Specific polymorphisms in genes such as SRD5D2, XPC, XPD, THADA, SUN2, PRKCI, PPARG, PCA3, KLK3, IL-8, ADIPOQ, GEMIN4, and RNASEL have been linked to PCa risk in European, Japanese, American, and African populations, showing either positive or negative effects [57, 61–65, 94, 106, 112, 116, 118, 122, 129, 130, 132, 139, 141, 143, 148]. The gene discussed is KLK3; the disease is posterior cortical atrophy.