Complementary tumor-targeted MMAE peptide-drug conjugates and ADCs were synthesized by coupling the identical MC-VC-PABC-MMAE drug-linker moiety to activable cell penetrating peptide (ACPP) or anti-HER3 antibody (CDX3379), generating ACPP-MMAE and CDX3379-MMAE (Fig. 2b)48. The gene discussed is ERBB3; the disease is neoplasm.